کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6224336 | 1607474 | 2013 | 8 صفحه PDF | دانلود رایگان |
ObjectiveTo test the hypothesis that a change in glycated hemoglobin (A1c) over a follow-up interval of approximately 2 years would be associated with concomitant changes in fasting lipids in individuals with type 1 diabetes (T1D).Study designAll subjects with T1D diagnosed in 2002-2005 in the SEARCH for Diabetes in Youth study with at least 2 study visits â¼12 and â¼24 months after an initial visit were included (age at initial visit, 10.6 ± 4.1 years; 48% female; diabetes duration, 10 ± 7 months; 76% non-Hispanic white; A1c = 7.7% ± 1.4%). Longitudinal mixed models were fit to examine the relationship between change in A1c and change in lipid levels (total cholesterol [TC], high-density lipoprotein-cholesterol [HDL-c], low-density lipoprotein-cholesterol [LDL-c], log triglycerides [TG], and non-HDL-c) with adjustment for possible confounders.ResultsChange in A1c over time was significantly associated with changes in TC, HDL-c, LDL-c, TG, and non-HDL-c over the range of A1c values. For example, for a person with an A1c of 10% and then a 2% decrease in A1c 2 years later (to 8%), the model predicted concomitant changes in TC (â0.29 mmol/L, â11.4 mg/dL), HDL-c (0.03 mmol/L, 1.3 mg/dL), LDL-c (â0.23 mmol/L, â9.0 mg/dL), and non-HDL-c (â0.32 mmol/L, â12.4 mg/dL) and an 8.5% decrease in TG (mmol/L).ConclusionsImproved glucose control over a 2-year follow-up was associated with a more favorable lipid profile but may be insufficient to normalize lipids in dyslipidemic T1D youth needing to decrease lipids to goal.
Journal: The Journal of Pediatrics - Volume 162, Issue 1, January 2013, Pages 101-107.e1