کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6224347 1607474 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hyperuricemia is Associated with Hypertension, Obesity, and Albuminuria in Children with Chronic Kidney Disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Hyperuricemia is Associated with Hypertension, Obesity, and Albuminuria in Children with Chronic Kidney Disease
چکیده انگلیسی

ObjectiveTo assess the prevalence and associations of hyperuricemia in a cohort of pediatric patients with chronic kidney disease (CKD).Study designThis was an observational cross-sectional study of clinical and laboratory data in pediatric patients being followed in a nephrology clinic. All patients with CKD were included. ORs and risk estimates of having stage III-V CKD (defined as an estimated glomerular filtration rate [eGFR] <60 mL/min/1.73 m2) with hyperuricemia were calculated. The relationships among eGFR, body mass index (BMI), and hyperuricemia were estimated using both correlation and regression models.ResultsA total of 116 children (61% male), aged 0.4-17 years, were included in the analysis. The prevalence of hyperuricemia in those with an eGFR <60 mL/min/1.73 m2 was 70%. Children with hyperuricemia were more likely to have an eGFR <60 mL/min/1.73 m2 than those with a normal urate level (OR, 4.6) and were more likely to be hypertensive (OR, 2.1). Hyperuricemia was significantly associated with increased BMI, albuminuria, renal dysfunction with reduced eGFR, and hypertension. Significant linear relationships between eGFR and urate (P = .0001) and between BMI and urate (P = .0001) were detected.ConclusionsHyperuricemia is common in pediatric patients with CKD and is associated with renal dysfunction, hypertension, obesity, and albuminuria. Future prospective studies should be undertaken to further assess the role of hyperuricemia in pediatric patients with CKD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Pediatrics - Volume 162, Issue 1, January 2013, Pages 128-132
نویسندگان
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