کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6225427 | 1607492 | 2011 | 7 صفحه PDF | دانلود رایگان |

ObjectiveTo analyze survival patterns among infants with hypoplastic left heart syndrome (HLHS) in the State of Michigan.Study designCases of HLHS prevalent at live birth were identified and confirmed within the Michigan Birth Defects Registry from 1992 to 2005 (n = 406). Characteristics of infants with HLHS were compared with a 10:1 random control sample.ResultsCompared with 4060 control subjects, the 406 cases of HLHS were more frequently male (62.6% vs 51.4%), born prematurely (<37 weeks gestation; 15.3% vs 8.7%), and born at low birth weight (LBW) (<2.5 kg; 16.0% vs 6.6%). HLHS 1-year survival rate improved over the study period (P = .041). Chromosomal abnormalities, LBW, premature birth, and living in a high poverty neighborhood were significantly associated with death. Controlling for neighborhood poverty, term infants versus preterm with HLHS or LBW were 3.2 times (95% CI: 1.9-5.3; P < .001) more likely to survive at least 1 year. Controlling for age and weight, infants from low-poverty versus high-poverty areas were 1.8 times (95% CI: 1.1-2.8; P = .015) more likely to survive at least 1 year.ConclusionsAmong infants with HLHS in Michigan, those who were premature, LBW, had chromosomal abnormalities, or lived in a high-poverty area were at increased risk for early death.
Journal: The Journal of Pediatrics - Volume 159, Issue 1, July 2011, Pages 57-63