کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6229508 1608118 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spontaneous neural activity in the right superior temporal gyrus and left middle temporal gyrus is associated with insight level in obsessive-compulsive disorder
ترجمه فارسی عنوان
فعالیت عصبی خود به خودی در گوروس عمیق راست و چپ وسط گوروش عمودی با سطح بینایی در اختلال وسواس فکری
کلمات کلیدی
اختلال وسواسی-اجباری، بینش، بصیرت، درون بینی، دامنه نوسانات فرکانس پایین، چپ گوریوس زمان متوسط راست جوراب بلند مرتبه
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
چکیده انگلیسی


- We used resting-state ALFF methods to explore the neural underpinnings of insight in OCD.
- Spontaneous neural activity in left MTG and right STG is associated with insight in OCD.
- Unique alterations in OCD-GI and OCD-PI were located mainly in temporo-occipital areas.
- Our results provide evidence for OCD-PI as a distinct subtype of OCD.

BackgroundInsight into illness is an important issue for psychiatry disorder. Although the existence of a poor insight subtype of obsessive-compulsive disorder (OCD) was recognized in the DSM-IV, and the insight level in OCD was specified further in DSM-V, the neural underpinnings of insight in OCD have been rarely explored. The present study was designed to bridge this research gap by using resting-state functional magnetic resonance imaging (fMRI).MethodsSpontaneous neural activity were examined in 19 OCD patients with good insight (OCD-GI), 18 OCD patients with poor insight (OCD-PI), and 25 healthy controls (HC) by analyzing the amplitude of low-frequency fluctuation (ALFF) in the resting state. Pearson correlation analysis was performed between regional ALFFs and insight levels among OCD patients.ResultsOCD-GI and OCD-PI demonstrated overlapping and distinct brain alterations. Notably, compared with OCD-GI, tOCD-PI had reduced ALFF in left middle temporal gyrus (MTG) and right superior temporal gyrus (STG), as well as increased ALFF in right middle occipital gyrus. Further analysis revealed that ALFF values for the left MTG and right STG were correlated negatively with insight level in patients with OCD.LimitationsRelatively small sample size and not all patients were un-medicated are our major limitations.ConclusionsSpontaneous brain activity in left MTG and right STG may be neural underpinnings of insight in OCD. Our results suggest the great role of human temporal brain regions in understanding insight, and further underscore the importance of considering insight presentation in understanding the clinical heterogeneity of OCD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 207, 1 January 2017, Pages 203-211
نویسندگان
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