کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6229591 1608121 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association between vitamin D and depressive symptoms varies by season: Results from the German Health Interview and Examination Survey for Adults (DEGS1)
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
پیش نمایش صفحه اول مقاله
Association between vitamin D and depressive symptoms varies by season: Results from the German Health Interview and Examination Survey for Adults (DEGS1)
چکیده انگلیسی


- There are conflicting reports on the association between vitamin D and depression.
- Vitamin D status is associated with depressive symptoms only in summer time.
- Vitamin D deficiency may be a consequence rather than a cause of depression.

BackgroundFindings from epidemiological studies regarding seasonal variations in the association between vitamin D status and depression are inconsistent.MethodsCross-sectional analysis of data from 6331 participants aged 18-79 years in the nationwide representative German Health Interview and Examination Survey for Adults 2008-2011 (DEGS1). Associations between 25-hydroxy-vitamin-D (25(OH)D) serum levels in quartiles and current depressive symptoms as measured by the Patient Health Questionnaire depression module (PHQ-9) and defined as severity of depressive symptoms (PHQ-9 score, range 0-27 points) and elevated depressive symptoms (PHQ-9 score ≥10 points) were analysed using multivariable linear and logistic regression adjusted for sociodemographic, biological and lifestyle factors. Analyses were stratified by summertime (May to October) and wintertime (November to April) because of evidence for interaction with season (p≤0.01).ResultsIn crude analyses, vitamin D status was inversely associated with both depression outcomes in summertime but not in wintertime. After adjustment for potential confounders, a significant association with severity of depressive symptoms remained in summer, with 0.73 point lower PHQ-9 scores in the highest versus lowest quartile. The association between 25(OH)D quartiles and elevated depressive symptoms in summertime was less strong and no longer significant in fully adjusted models.LimitationsParticipants with severe depression may be underrepresented in DEGS1. Residual confounding cannot be excluded.Conclusion25(OH)D serum levels were inversely associated with current depressive symptoms in summer but not in wintertime. The fact that the association is stronger in summertime suggests that vitamin D deficiency may be a consequence rather than a cause of depression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 204, 1 November 2016, Pages 92-98
نویسندگان
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