کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6230311 1608129 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research paperThe rapid suicide protection of mood stabilizers on patients with bipolar disorder: A nationwide observational cohort study in Taiwan
ترجمه فارسی عنوان
حفاظت سریع خودکشی از تثبیت کننده های خلق در بیماران مبتلا به اختلال دوقطبی: یک مطالعه کوهورت مشاهدات در سراسر کشور در تایوان
کلمات کلیدی
اختلال دو قطبی، خودکشی کردن، عوامل تثبیت کننده حالت، بانک اطلاعات بهداشتی ملی،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
چکیده انگلیسی


- Rapid use of three mood-stabilizers reduced suicide-related events among BD patients.
- We focused on the effect of the final prescription time period of mood-stabilizers.
- When suicidal idea in BD is identified, the use of mood-stabilizers early is suggested.

BackgroundThe suicide rate is high among bipolar disorder (BD) patients. Previous studies have focused on the anti-suicidal effect of long-term treatment with mood stabilizers but less on the immediate preventive effects of interventions. The aim of the study was to evaluate the short-term and immediate anti-suicidal effects of mood stabilizers on recent-onset BD patients.MethodsThe National Health Insurance Database (NHID) of Taiwan was used to perform a nationwide cohort observation study of suicide behaviors in bipolar disorder. All the recent-onset BD patients (ICD-9-CM code 296 except 296.2 and 296.3) diagnosed between 2000-2005 were collected (n=5091) and followed through 2009. The primary endpoint was the presence of a suicide code or the end of observation; exposure to mood stabilizers in the final month of observation was the independent variable.ResultsThe hazard ratios (HRs) of suicide-related events, completed suicide, and all-cause mortality were significantly lower for those treated with lithium, divalproex, or carbamazepine compared with no use in the last month (HRs of suicide-related events were 0.10, 0.14 and 0.10, respectively, and all-cause mortality HRs were 0.03; P<0.0001); there was no significant difference in HR between the mood stabilizers.LimitationsThe NIHD does not provide information on the severity, mood status, or treatment adherence of BD patients. Neither substance-related disorder nor personality disorder were included in the analysis. We focused on the effect of the final prescription time period, not the long-term protective effect.ConclusionsThe immediate recent use of any mood stabilizer significantly lowers the rate of death, suicide, or suicidal behavior in BD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 196, 15 May 2016, Pages 71-77
نویسندگان
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