کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6230429 1608132 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Abnormal default-mode network homogeneity and its correlations with personality in drug-naive somatization disorder at rest
ترجمه فارسی عنوان
همگن بودن شبکه حالت پیش فرض حالت غیر عادی و همبستگی آن با شخصیت در اختلال سوء تغذیه نامطلوب در حالت استراحت
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
چکیده انگلیسی


- Abnormal DMN homogeneity was present in SD patients.
- A negative correlation between NH values in the bilateral PCu and EPQ-N in SD.
- SD patients were drug-naive individuals.

BackgroundWhile the default-mode network (DMN) appears to play a crucial role in patients suffering from somatization disorder (SD), the abnormalities of the network homogeneity (NH) of the DMN in SD patients have been poorly explored. The aim of this study is to examine DMN NH using an NH approach in patients suffering from SD at rest and determine its correlations with personality as measured by the Eysenck Personality Questionnaire (EPQ).MethodsA total of 25 drug-naive patients with SD and 28 sex-, age-, and education-matched healthy controls underwent functional magnetic resonance imaging scans at rest. The data were analyzed by an automated NH method.ResultsPatients showed increased NH in the left superior frontal gyrus and decreased NH in the bilateral precuneus. Moreover, a significantly negative correlation was observed between the NH values in the bilateral precuneus and the EPQ­-Neuroticism scores.LimitationsThe present study should be considered preliminary due to a lenient, uncorrected threshold of p<0.01.ConclusionsThe results suggest that abnormal DMN NH exists in drug-naive SD and further highlight the importance of the DMN in the pathophysiology of SD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 193, 15 March 2016, Pages 81-88
نویسندگان
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