کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6230457 | 1608132 | 2016 | 10 صفحه PDF | دانلود رایگان |

- fMRI small-worldness is lower in OCD children suggesting inefficient neuronetworks.
- Modularity is lower in OCD children suggesting alternative brain organization.
- Local clustering coefficient is higher in OCD in severalbrain regions.
- Local betweenness centrality is lower in OCD in the same regions.
BackgroundfMRI graph theory reveals resting-state brain networks, but has never been used in pediatric OCD.MethodsWhole-brain resting-state fMRI was acquired at 3 T from 21 children with OCD and 20 age-matched healthy controls. BOLD connectivity was analyzed yielding global and local graph-theory metrics across 100 child-based functional nodes. We also compared local metrics between groups in frontopolar, supplementary motor, and sensorimotor cortices, regions implicated in recent neuroimaging and/or brain stimulation treatment studies in OCD.ResultsAs in adults, the global metric small-worldness was significantly (P<0.05) lower in patients than controls, by 13.5% (%mean difference=100%X(OCD mean - control mean)/control mean). This suggests less efficient information transfer in patients. In addition, modularity was lower in OCD (15.1%, P<0.01), suggesting less granular - or differently organized - functional brain parcellation. Higher clustering coefficients (23.9-32.4%, P<0.05) were observed in patients in frontopolar, supplementary motor, sensorimotor, and cortices with lower betweenness centrality (â63.6%, P<0.01) at one frontopolar site. These findings are consistent with more locally intensive connectivity or less interaction with other brain regions at these sites.LimitationsRelatively large node size; relatively small sample size, comorbidities in some patients.ConclusionsPediatric OCD patients demonstrate aberrant global and local resting-state network connectivity topologies compared to healthy children. Local results accord with recent views of OCD as a disorder with sensorimotor component.
Journal: Journal of Affective Disorders - Volume 193, 15 March 2016, Pages 175-184