کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6231114 | 1608139 | 2015 | 5 صفحه PDF | دانلود رایگان |

- Patients who were unable to tolerate standard 10Â Hz rTMS were switched to 5Â Hz rTMS.
- Higher baseline levels of depression and anxiety were found in 5Â Hz patients.
- 5Â Hz rTMS provided the same clinical outcomes as 10Â Hz rTMS.
- Power was sufficient to detect small differences between groups.
BackgroundRepetitive transcranial magnetic stimulation (rTMS) to left prefrontal cortex at 10Â Hz is the most commonly utilized protocol for major depressive disorder (MDD). Published data suggests that left sided 5Â Hz rTMS may be efficacious and well tolerated.ObjectiveWe analyzed outcomes in a naturalistic cohort of MDD patients who could not tolerate 10Â Hz rTMS and were routinely switched to 5Â Hz. We hypothesized that the efficacy of 5Â Hz rTMS would be equivalent to 10Â Hz.MethodsRecords were reviewed for patients (n=98) who received 15 or more acute rTMS treatments. The sample was split based upon the frequency (10 or 5Â Hz) at which the majority of treatments were delivered. The Inventory of Depressive Symptoms (IDS-SR) and 9-Item Patient Health Questionnaire (PHQ-9) were used to evaluate outcomes.ResultsBaseline IDS-SR was higher in the 5Â Hz (n=27) than in the 10Â Hz (n=71) group (p<.05), as was frequency of comorbid anxiety (p=.002). Depression outcomes did not differ between groups, and there were no differences in response or remission rates (all p>.1). Statistical power was sufficient to detect small group differences (d=.26).LimitationsOpen-label data in a naturalistic setting.ConclusionOutcomes associated with 5Â Hz rTMS did not differ from 10Â Hz, despite higher baseline depressive symptom severity and anxiety in 5Â Hz patients. 5Â Hz stimulation may be an alternative treatment option for patients unable to tolerate 10Â Hz rTMS.
Journal: Journal of Affective Disorders - Volume 186, 1 November 2015, Pages 13-17