کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6231678 1608151 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Implicit motor learning in bipolar disorder
ترجمه فارسی عنوان
یادگیری حرکتی غیرمعمول در اختلال دوقطبی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
چکیده انگلیسی

ObjectivesA growing number of publications describe cerebellar abnormalities in patients with bipolar disorder (BD). The aim of the following paper was to examine the functional aspects of that issue by focusing on implicit learning - a cognitive function with significant cerebellar underpinnings.Methods27 patients with BD and 26 healthy controls (HC), matched for age and sex took part in the study. Implicit motor learning was assessed by the serial reaction time task (SRTT), in which participants were unconsciously learning a sequence of motor reactions. The indicators of procedural learning were the decrease of reaction time (RT) across the repetition of the sequence and the rebound of RT when the sequence changed into a random set of stimuli.ResultsBD patients did not present any indicators of the implicit learning, their RT increased across repetitions of the sequence and it decreased when the sequence changed to random. Contrary, in the control group RT decreased across the sequence repetitions and increased when the stimuli begun to appear randomly.LimitationsA low subject count and a non-drug naïve patients group, medicated with atypical antipsychotic and mood stabilizers, are the most significant limitations of this study.ConclusionsBD patients did not acquire procedural knowledge while performing the task, whereas HC did. To our knowledge this is the first study that shows the impairment of implicit motor learning in patients with BD. This indicates the possible cerebellar dysfunction in this disease and may provide a new neuropsychiatric approach to bipolar disorder.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 174, 15 March 2015, Pages 250-256
نویسندگان
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