کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6233195 1608171 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mixed-state bipolar I and II depression: Time to remission and clinical characteristics
ترجمه فارسی عنوان
افسردگی دوطرفه ای دو طرفه و حالت دوم: زمان بهبودی و ویژگی های بالینی
کلمات کلیدی
افسردگی دوقطبی، حالت مخلوط افسردگی، تعریف بناززی، ریزش، ویژگی های بالینی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
چکیده انگلیسی

BackgroundWe compared the time to achieve remission and the clinical characteristics of patients with bipolar depressive mixed state and those with bipolar depressive non-mixed state.MethodsThe subjects (N=131) were inpatients diagnosed between 2006 and 2012 with bipolar I or II disorder, depression and were classified into the following three groups: “pure depressive state” (PD, n=70), “sub-threshold mixed state” (SMX, n=38), and “depressive mixed state” (DMX, n=23). Diagnosis of a DMX was in accordance with Benazzi's definition: three or more manic symptoms in a depressive episode. The subjects' charts were retrospectively reviewed to ascertain the time to achieve remission from the index episode and to identify other factors, such as demographic and clinical characteristics, specific manic symptoms, and pharmacological treatment, that may have contributed to remission.ResultsThe time to achieve remission was significantly longer in the DMX (p=0.022) and SMX (p=0.035) groups than in the PD group. Adjustment for covariates using a Cox proportional hazards model did not change these results. Clinically, subjects with a DMX were more likely to have manic symptoms in the index episode, especially inflated self-esteem and psychomotor agitation than those in the PD.LimitationsWe investigated only inpatients and therefore could not comment on outpatients.ConclusionsThese findings showed that sub-syndromal manic symptoms in bipolar depression had different clinical characteristics and a more severe illness course, including a longer time to achieve remission, than did a pure depressive state.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volumes 152–154, January 2014, Pages 340-346
نویسندگان
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