کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6233612 1608172 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tardive dyskinesia from atypical antipsychotic agents in patients with mood disorders in a clinical setting
ترجمه فارسی عنوان
دیسکینزی دائمی از داروهای ضد سایکوتیک غیرطبیعی در بیماران مبتلا به اختلالات خلقی در محیط بالینی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
چکیده انگلیسی

BackgroundThere is a paucity of information on the risks and clinical characteristics of tardive dyskinesia with atypical antipsychotic agents in patients with mood and anxiety disorders in clinical practice.Methods: The authors retrospectively screened the charts of 268 patients with a mood or anxiety disorder treated with atypical antipsychotic agents from a psychiatric practice. Fifteen patients who developed tardive dyskinesia were identified and further data was collected on these patients.ResultsTardive dyskinesia occurred in 5.9% of patients after exposure to an atypical antipsychotic agent for a mean of 28.7 months (range: 1-83). The average dosage of the offending agent in chlorpromazine equivalents was 350 mg/day (range: 67-969). All patients experienced oral-buccal-lingual stereotypy, which was frequently severe in nature, but completely resolved in all but one patient. Most patients (90.9%) who consented to a second trial of an atypical antipsychotic did not experience a relapse of TD.Limitations: All patients were treated in a clinical practice setting by a single psychiatrist, which may limit the generalizability of the findings.ConclusionsThe observed rate of TD represents a real world estimate of the risk of TD with atypical antipsychotic agents in patients with mood disorders. Fortunately, with early recognition symptoms appear to be reversible and further treatment with another atypical antipsychotic does not necessarily lead to relapse.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 150, Issue 3, 25 September 2013, Pages 868-871
نویسندگان
, , ,