کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6233969 1277554 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The retinoid-related orphan receptor alpha (RORA) gene and fear-related psychopathology
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
پیش نمایش صفحه اول مقاله
The retinoid-related orphan receptor alpha (RORA) gene and fear-related psychopathology
چکیده انگلیسی

BackgroundThis study followed on findings from a recent genome-wide association study of PTSD that implicated the retinoid-related orphan receptor alpha (RORA) gene (Logue et al., 2012) by examining its relationship to broader array of disorders.MethodsUsing data from the same cohort (N=540), we analyzed patterns of association between 606 single nucleotide polymorphisms (SNPs) spanning the RORA gene and comorbidity factors termed fear, distress (i.e., internalizing factors) and externalizing.ResultsResults showed that rs17303244 was associated with the fear component of internalizing (i.e., defined by symptoms of panic, agoraphobia, specific phobia, and obsessive-compulsive disorder) at a level of significance that withstood correction for gene-wide multiple testing.LimitationsThe primary limitations were the modest size of the cohort and the absence of a replication sample.ConclusionsResults add to a growing literature implicating the RORA gene in a wide range of neuropsychiatric disorders and offer new insight into possible molecular mechanisms of the effects of traumatic stress on the brain and the role of genetic factors in those processes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 151, Issue 2, November 2013, Pages 702-708
نویسندگان
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