کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6234535 | 1277561 | 2013 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Anti-anxiety drugs reduce conflict-specific “theta”-A possible human anxiety-specific biomarker Anti-anxiety drugs reduce conflict-specific “theta”-A possible human anxiety-specific biomarker](/preview/png/6234535.png)
BackgroundSyndromes of fear/anxiety are currently ill-defined, with no accepted human biomarkers for anxiety-specific processes. A unique common neural action of different classes of anxiolytic drugs may provide such a biomarker. In rodents, a reduction in low frequency (4-12Â Hz; “theta”) brain rhythmicity is produced by all anxiolytics (even those lacking panicolytic or antidepressant action) and not by any non-anxiolytics. This rhythmicity is a key property of the Behavioural Inhibition System (BIS) postulated to be one neural substrate of anxiety. We sought homologous anxiolytic-sensitive changes in human surface EEG rhythmicity.MethodThirty-four healthy volunteers in parallel groups were administered double blind single doses of triazolam 0.25Â mg, buspirone 10Â mg or placebo 1 hour prior to completing the stop-signal task. Right frontal conflict-specific EEG power (previously shown to correlate with trait anxiety and neuroticism in this task) was extracted as a contrast between trials with balanced approach-avoidance (stop-go) conflict and the average of trials with net approach and net avoidance.ResultsCompared with placebo, both triazolam and buspirone decreased right-frontal, 9-10Â Hz, conflict-specific-power.LimitationsOnly one dose of each of only two classes of anxiolytic and no non-anxiolytics were tested, so additional tests are needed to determine generality.ConclusionsThere is a distinct rhythmic system in humans that is sensitive to both classical/GABAergic and novel/serotonergic anxiolytics. This conflict-specific rhythmicity should provide a biomarker, with a strong pre-clinical neuropsychology, for a novel approach to classifying anxiety disorders.
Journal: Journal of Affective Disorders - Volume 148, Issue 1, 15 May 2013, Pages 104-111