کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6236047 | 1608183 | 2012 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The sustained mood-stabilizing effect of memantine in the management of treatment resistant bipolar disorders: Findings from a 12-month naturalistic trial The sustained mood-stabilizing effect of memantine in the management of treatment resistant bipolar disorders: Findings from a 12-month naturalistic trial](/preview/png/6236047.png)
BackgroundWe have recently provided preliminary clinical observations indicating that memantine, as augmenting agent, was associated with a meaningful antimanic and mood-stabilizing effect in treatment-resistant bipolar disorders. To further investigate the therapeutic and prophylactic action of the drug we administered memantine, as augmenting agent, to 40 treatment-resistant bipolar disorder patients, monitored and evaluated for 12Â months.MethodsThe sample population encompassed 40 treatment-resistant bipolar disorder patients monitored for 12Â months. Memantine, at the dose of 10-30Â mg/day, was added to the ongoing treatment, which was left unmodified. The severity of the patients' condition before memantine and the changes after memantine addition were evaluated on the Clinical Global Impression Bipolar (CGI-BP) Overall Bipolar Illness Scale. The severity of patients' condition was scored before memantine and the change was evaluated after memantine addition at 6 and 12Â months.LimitationsThe present study has the limitations of an open clinical study and the observed effects require testing in a blinded, randomized, controlled trial which is planned.ResultsThe average CGI-BP score of the patients was 6.7 (SDÂ =Â 0.58, range: 5-7) before the addition of memantine. After 6Â months of memantine treatment, 72.5% of patients were very much or much improved. Among the rapid cyclers 68.4% of patients reached stability, defined by the absence of recurrences.Patients very much or much improved were 72.5% at 12Â months; while 12.5% discontinued memantine or were lost to follow-up.ConclusionsThe results confirm our previous observations and strongly suggest that memantine, as augmenting agent, was associated with a clinically substantial antimanic and sustained mood-stabilizing effect, with excellent safety and tolerability profile.
Journal: Journal of Affective Disorders - Volume 136, Issues 1â2, January 2012, Pages 163-166