کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6236358 | 1608195 | 2010 | 7 صفحه PDF | دانلود رایگان |

ObjectiveThe polymorphism BDNF val66met of the brain derived neurotrophic factor (BDNF) is common, may increase the risk for depression, and affects BDNF secretion, critical for neuronal survival, plasticity, neurogenesis, and synaptic connectivity. Our objectives were: 1) to test the hypothesis that BDNFval/met status influences the remission rate of geriatric depression; 2) to explore whether the relationship between BDNF allelic status to remission is influenced by the presence of microstructural white matter abnormalities.MethodNonâdemented older subjects with major depression had a 2âweek placebo period, after which those with a Hamilton Depression Rating Scale (HDRS) of 18 or greater received escitalopram 10Â mg daily for 12Â weeks. Fractional anisotropy was determined in specific regions using the Reproducible Object Quantification Scheme (ROQS) software that operates on nonânormalized data.ResultsBDNFmet carriers were more likely to achieve remission than BDNFval/val homozygotes after 12Â weeks of treatment with escitalopram 10Â mg daily. Microstructural abnormalities in the corpus callosum, left superior corona radiata, and right inferior longitudinal fasciculum were also associated with lower remission rate. However, there were no significant interactions between BDNFval66met status and microstructural abnormalities in predicting remission.LimitationsSmall number of subjects, focus on a single BDNF polymorphism, fixed antidepressant dose.ConclusionsDepressed older BDNFmet carriers had a higher remission rate than BDNFval/val homozygotes. This effect was not related to microstructural white matter abnormalities, which predicted remission independently. We speculate that the relationship between BDNFval66met and remission is due to different effects of BDNF in brain structures related to mood regulation.
Journal: Journal of Affective Disorders - Volume 125, Issues 1â3, September 2010, Pages 262-268