کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6236394 1608195 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
پیش نمایش صفحه اول مقاله
Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder
چکیده انگلیسی

BackgroundGene-environment interactions may contribute to the high heritability of bipolar affective disorder. The aim of the present study was to examine the interplay between the BDNF Val66Met polymorphism and stressful life events (SLEs) in bipolar disorder.MethodA total of 1085 participants were recruited, including 487 bipolar I cases and 598 psychiatrically healthy controls. All participants completed the List of Threatening Life Events Questionnaire; bipolar subjects reported the events that occurred 6 months leading up to their worst manic episode and 6 months prior to their worst depressive episode, controls recorded events experienced 6 months before interview. The sample was genotyped for the BDNF Val66Met polymorphism (rs6265).ResultsBoth Met carrier BDNF genotype and SLEs were significantly associated with the worst depressive episode of bipolar disorder. For the worst depressive episodes the effects of SLEs were also significantly moderated by BDNF genotype (gene × environment interaction).LimitationsThe use of a self report questionnaire to measure stressful life events may increase recall inaccuracies, therefore caution should be taken when interpreting these results.DiscussionThe findings of this study highlight the importance of the interplay between genes and the environment in bipolar disorder.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 125, Issues 1–3, September 2010, Pages 345-349
نویسندگان
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