کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6236520 | 1608197 | 2010 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Early response to selective serotonin reuptake inhibitors in panic disorder is associated with a functional 5-HT1A receptor gene polymorphism Early response to selective serotonin reuptake inhibitors in panic disorder is associated with a functional 5-HT1A receptor gene polymorphism](/preview/png/6236520.png)
BackgroundPanic disorder is a common and disabling condition which can be treated with selective serotonin reuptake inhibitors (SSRIs). Although many subjects respond well to such treatment, there is substantial inter-individual variation implicating genetic factors.Methods102 patients with a diagnosis of panic disorder receiving sertraline or paroxetine took part in study. Hospital Anxiety and Depression Scale score, CGI and panic attack frequency (per month) were assessed before and after 6 weeks of SSRI treatment with 1 week of titration period. All patients were genotyped for the â 1019C/G 5-HT1A receptor and ins/del 5-HT transporter polymorphisms.ResultsThe 5-HT1A receptor â 1019C/G polymorphism was strongly associated with response to treatment, in which 20 subjects with the GG genotype showed minimal changes in panic attack frequency with a relative risk of no response of 4.73. This association was also found with each drug independently. However, no association of the ins/del 5-HT transporter polymorphism with treatment response was observed.LimitationsLarger numbers of subjects and longer period of SSRI treatment would confirm and strengthen these preliminary findings.ConclusionThese results indicate the importance of a 5-HT1A receptor gene polymorphism in the response to SSRI treatment of panic disorder.
Journal: Journal of Affective Disorders - Volume 123, Issues 1â3, June 2010, Pages 308-311