کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6236600 1608201 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Normal glutamate but elevated myo-inositol in anterior cingulate cortex in recovered depressed patients
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
پیش نمایش صفحه اول مقاله
Normal glutamate but elevated myo-inositol in anterior cingulate cortex in recovered depressed patients
چکیده انگلیسی

BackgroundMRS studies of acutely depressed patients reveal decreased levels of total glutamate and glutamine (Glx) in frontal cortex which may reflect abnormalities of glutamate-glutamine cycling through astrocytes. Frontal Glx levels appear to be normalised after recovery from depression, but it is not known if this composite measure masks ongoing differences in glutamate or glutamine alone.MethodsMedication-free, fully recovered patients with a history of DSM-IV recurrent major depressive disorder (n = 14) and healthy controls (n = 16) were scanned at 3T. Short echo time PRESS and PRESS-J spectra were acquired from a 12 cm3 voxel of frontal cortex incorporating the anterior cingulate.ResultsLevels of Glx and of glutamate alone did not differ between groups. However, myo-inositol concentrations were significantly higher in those with a history of depression than in controls.LimitationsAbnormal MRS measures were not demonstrated during episodes of depression for these participants, so any evidence of changes with recovery is indirect.ConclusionsThe normal glutamatergic measures combined with elevated levels of the astrocytic marker, myo-inositol, suggest that recovery from depression may be associated with changes in glial function in frontal cortex.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 119, Issues 1–3, December 2009, Pages 186-189
نویسندگان
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