کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6236885 1608214 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Early-emerging cognitive vulnerability to depression and the serotonin transporter promoter region polymorphism
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
پیش نمایش صفحه اول مقاله
Early-emerging cognitive vulnerability to depression and the serotonin transporter promoter region polymorphism
چکیده انگلیسی

BackgroundSerotonin transporter promoter (5-HTTLPR) genotype appears to increase risk for depression in the context of stressful life events. However, the effects of this genotype on measures of stress sensitivity are poorly understood. Therefore, this study examined whether 5-HTTLPR genotype was associated with negative information processing biases in early childhood.MethodThirty-nine unselected seven-year-old children completed a negative mood induction procedure and a Self-Referent Encoding Task designed to measure positive and negative schematic processing. Children were also genotyped for the 5-HTTLPR gene.ResultsChildren who were homozygous for the short allele of the 5-HTTLPR gene showed greater negative schematic processing following a negative mood prime than those with other genotypes. 5-HTTLPR genotype was not significantly associated with positive schematic processing.LimitationsThe sample size for this study was small. We did not analyze more recently reported variants of the 5-HTTLPR long alleles.Conclusions5-HTTLPR genotype is associated with negative information processing styles following a negative mood prime in a non-clinical sample of young children. Such cognitive styles are thought to be activated in response to stressful life events, leading to depressive symptoms; thus, cognitive styles may index the “stress-sensitivity” conferred by this genotype.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 107, Issues 1–3, April 2008, Pages 227-230
نویسندگان
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