کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6240315 | 1280420 | 2015 | 7 صفحه PDF | دانلود رایگان |
BackgroundCftrâ/â tm1Unc mice develop progressive hepato-biliary pathology. We hypothesize that this liver pathology is related to alterations in biliary bile hydrophobicity and bile salt metabolism in Cftrâ/âtm1Unc mice.MethodsWe determined bile production, biliary and fecal bile salt- and lipid compositions and fecal bacterial composition of C57BL/6 J Cftrâ/âtm1Unc and control mice.ResultsWe found no differences between the total biliary bile salt or lipid concentrations of Cftrâ/â and controls. Compared to controls, Cftrâ/â mice had a ~ 30% higher bile production and a low bile hydrophobicity, related to a ~ 7 fold higher concentration of the choleretic and hydrophilic bile salt ursocholate. These findings coexisted with a significantly smaller quantity of fecal Bacteroides bacteria.ConclusionsLiver pathology in Cftrâ/âtm1Unc is not related to increased bile hydrophobicity. Cftrâ/â mice do however display a biliary phenotype characterized by increased bile production and decreased biliary hydrophobicity. Our findings suggest Cftr dependent, alterations in intestinal bacterial biotransformation of bile salts.
Journal: Journal of Cystic Fibrosis - Volume 14, Issue 4, July 2015, Pages 440-446