کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6240900 1280443 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dynamic vascular changes following intravenous antibiotics in patients with cystic fibrosis
ترجمه فارسی عنوان
تغییرات پویایی عروقی پس از آنتی بیوتیک های وریدی در بیماران مبتلا به فیبروز کیستیک
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
چکیده انگلیسی

BackgroundAdults with cystic fibrosis (CF) have altered large artery haemodynamics which is associated with a persisting systemic inflammatory state. We hypothesized that a short-term intervention favorably influencing the inflammatory status may modify their haemodynamic state.MethodsAdult patients with CF were studied immediately preceding and following 2 weeks of intravenous antibiotics. Large artery haemodynamics, principally heart rate-adjusted augmentation index (AIx) were obtained. Blood pressure (BP), spirometry and CRP were also measured.ResultsComplete data was available for 15 patients; mean (SD) age 28 (6) years. CRP was reduced while FEV1% predicted improved. Following treatment AIx was lower: 10.9 (10.9)% to 8.1 (10.9)% (p < 0.05) while BP was similar and a trend toward lower heart rate (p = 0.06). Change in AIx was related to baseline FEV1% predicted (r = 0.77) and BMI (r = 0.71) (both P < 0.01).ConclusionThe abnormal central haemodynamics evident in adults with CF is modulated with a short intervention of intravenous antibiotics.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cystic Fibrosis - Volume 12, Issue 2, March 2013, Pages 125-129
نویسندگان
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