کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6240969 1280449 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Left ventricular and aortic dysfunction in cystic fibrosis mice
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Left ventricular and aortic dysfunction in cystic fibrosis mice
چکیده انگلیسی

BackgroundLeft ventricular (LV) abnormalities have been reported in cystic fibrosis (CF); however, it remains unclear if loss of cystic fibrosis transmembrane conductance regulator (CFTR) function causes heart defects independent of lung disease.MethodsUsing gut-corrected F508del CFTR mutant mice (ΔF508), which do not develop human lung disease, we examined in vivo heart and aortic function via 2D transthoracic echocardiography and LV catheterization.ResultsΔF508 mouse hearts showed LV concentric remodeling along with enhanced inotropy (increased + dP/dt, fractional shortening, decreased isovolumetric contraction time) and greater lusitropy (− dP/dt, Tau). Aortas displayed increased stiffness and altered diastolic flow. β-adrenergic stimulation revealed diminished cardiac reserve (attenuated + dP/dt,− dP/dt, LV pressure).ConclusionsIn a mouse model of CF, CFTR mutation leads to LV remodeling with alteration of cardiac and aortic functions in the absence of lung disease. As CF patients live longer, more active lives, their risk for cardiovascular disease should be considered.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cystic Fibrosis - Volume 12, Issue 5, September 2013, Pages 517-524
نویسندگان
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