کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6241890 | 1280567 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of lung function and deposition of aerosolized bronchodilators carried by heliox associated with positive expiratory pressure in stable asthmatics: A randomized clinical trial
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
Intermittent positive pressure breathingSBPIPPBDBPEPAPPEEPSpO2PEFPEPCPAPFVCFEV1PEEPi - PEEPROIs - ROI هاAerosol - آئروسلAsthma - آسمPeripheral oxygen saturation - اشباع اکسیژن محیطیCOPD - بیماری مزمن انسدادی ریهChronic obstructive pulmonary disease - بیماری مزمن انسدادی ریهPeak expiratory flow - جریان انقباض قلهForced Expiratory Volume in the first second - دوره انجماد اجباری در اولین مرحلهHeart rate - ضربان قلبinspiratory capacity - ظرفیت انجمادforced vital capacity - ظرفیت حیاتی اجباریPositive end expiratory pressure - فشار بیرونی انتهای مثبتContinuous positive airway pressure - فشار جریان هوای همواره مثبتdiastolic blood pressure - فشار خون دیاستولیکsystolic blood pressure - فشار خون سیستولیکPositive expiratory pressure - فشار مثبت بیحسیexpiratory positive airway pressure - فشار هوای مثبت هوایی بیحسیRegions Of Interest - مناطق مورد علاقهrespiratory rate - نرخ تنفسHelium - هلیم
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
While administration of medical aerosols with heliox and positive airway pressure are both used clinically to improve aerosol delivery, few studies have differentiated their separate roles in treatment of asthmatics. The aim of this randomized, double blinded study is to differentiate the effect of heliox and oxygen with and without positive expiratory pressure (PEP), on delivery of radiotagged inhaled bronchodilators on pulmonary function and deposition in asthmatics. 32 patients between 18 and 65 years of age diagnosed with stable moderate to severe asthma were randomly assigned into four groups: (1) Heliox + PEP (n = 6), (2) Oxygen + PEP (n = 6), (3) Heliox (n = 11) and (4) Oxygen without PEP (n = 9). Each group received 1 mg of fenoterol and 2 mg of ipratropium bromide combined with 25 mCi (955 Mbq) of Technetium-99m and 0.9% saline to a total dose volume of 3 mL placed in a Venticis® II nebulizer attached to a closed, valved mask with PEP of 0 or 10 cm H2O. Both gas type and PEP level were blinded to the investigators. Images were acquired with a single-head scintillation camera with the longitudinal and transverse division of the right lung as regions of interest (ROIs). While all groups responded to bronchodilators, only group 1 showed increase in FEV1%predicted and IC compared to the other groups (p < 0.04). When evaluating the ROI in the vertical gradient we observed higher deposition in the middle and lower third in groups 1 (p = 0.02) and 2 (p = 0.01) compared to group 3. In the horizontal gradient, a higher deposition in the central region in groups 1 (p = 0.03) and 2 (p = 0.02) compared to group 3 and intermediate region of group 2 compared to group 3. We conclude that aerosol deposition was higher in groups with PEP independent of gas used, while bronchodilator response with Heliox + PEP improved FEV1 % and IC compared to administration with Oxygen, Oxygen with PEP and Heliox alone. Trial registration NCT01268462.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Medicine - Volume 107, Issue 8, August 2013, Pages 1178-1185
Journal: Respiratory Medicine - Volume 107, Issue 8, August 2013, Pages 1178-1185
نویسندگان
Luciana Alcoforado, Simone Brandão, Catarina Rattes, Daniella Brandão, Vitória Lima, Gildo Ferreira Lima, James B. Fink, Armele Dornelas de Andrade,