کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6242073 | 1280574 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pneumococcal vaccination in adults: Does it really work?
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کلمات کلیدی
PCV7PPV23PCV13PPVEfficacy - اثرCommunity acquired pneumonia - جامعه، پنومونی را به دست آوردConjugate - مزدوجVaccine - واکسن7-valent pneumococcal conjugate vaccine - واکسن سرم پنوموکوک 7 واگنPneumococcal conjugate vaccine - واکسن مونوژئاز پنوموکوکPneumococcal polysaccharide vaccine - واکسن پلی ساکارید پنوموکوک23-Valent pneumococcal polysaccharide vaccine - واکسن پلی ساکارید پنوموکوک 23 ساله13-Valent pneumococcal conjugate vaccine - واکسن پنوموکوک کاندیدای 13 ساعتهPCV یا Pneumococcal conjugate vaccine - واکسن کونژوگه پنوموکوکPneumococcus - پنوموکوکPolysaccharide - چندقندی ها یا پلیساکاریدهاCaP - کلاه لبه دار
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The universal burden of pneumococcal disease is high. As pneumococcal capsular antigens induce serotype specific antibodies, both the available vaccines (polysaccharide and polysaccharide conjugated) are able to produce serological response. However, there is reasonable skepticism about the effectiveness and efficacy of the 23-valent polysaccharide vaccine, especially in the elderly and in immunocompromised adults. Results from numerous studies are conflicting but the more recent data suggest that polysaccharide vaccine raises inadequate protection against non-bacteremic pneumonia, while the benefit against invasive pneumococcal disease in high-risk population is uncertain. On the contrary, conjugate vaccine, -originally indicated only for infants and young children- appears to be highly effective but it does not cover the tremendous diversity of pneumococcal serotypes being able to cause disease in adults. Despite this, there is growing evidence that conjugate vaccines, due to their superior immunogenicity, could also be offered for adult vaccination, but still there are certain issues that warrant further investigation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Medicine - Volume 105, Issue 12, December 2011, Pages 1776-1783
Journal: Respiratory Medicine - Volume 105, Issue 12, December 2011, Pages 1776-1783
نویسندگان
Georgia G. Pitsiou, Ioannis P. Kioumis,