کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6246322 | 1284488 | 2014 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Emerging Trends in TransplantationExperimental transplantationThe Benefits of Hypothermic Machine Perfusion Are Enhanced With Vasosol and α-Tocopherol in Rodent Donation After Cardiac Death Livers Emerging Trends in TransplantationExperimental transplantationThe Benefits of Hypothermic Machine Perfusion Are Enhanced With Vasosol and α-Tocopherol in Rodent Donation After Cardiac Death Livers](/preview/png/6246322.png)
The use of hypothermic machine perfusion (HMP) has recently been used to show an improvement in both standard and extended criteria donor liver grafts but creating a more dynamic preservation environment that can be supplemented with a variety of additives to aid in cold temperature metabolism and vasodilatation. Increasing the benefits of HMP, we explore the use of α-tocopherol in reducing inflammatory markers and apoptotic pathways to reduce the incidence of preservation injury. We explored the use of a donation after cardiac death (DCD) rodent model to test the additive benefits of α-tocopherol in HMP. The addition of α-tocopherol reduced the level of alanine aminotransferase (ALT) over the course of reperfusion as well, reduced the levels of inflammatory cytokines within a 90 minute reperfusion biopsy. Further benefit was seen with α-tocopherol through the reduction of the level of caspase 3/7 in the circulation, shown to be a result of the reduction of the levels of Cytochrome C mRNA. Liver perfusion with Vasosol® and HMP could benefit further from the addition of α-tocopherol to existing formulations of Vasosol®.
Journal: Transplantation Proceedings - Volume 46, Issue 5, June 2014, Pages 1560-1566