کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6247078 | 1284513 | 2016 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Light Chain Deposition Disease After Kidney Transplantation With Long Graft Survival: Case Report
ترجمه فارسی عنوان
بیماری لثه زنجیره ای پس از پیوند کلیه با بقای طولانی پیوند: گزارش مورد
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
عمل جراحی
چکیده انگلیسی
Light Chain Deposition Disease (LCDD) is a monoclonal immunoglobulin deposition disease that commonly affects kidneys among other organs. It leads to end-stage renal disease and has a high disease recurrence rate after kidney transplantation. This has led some authors to advise against transplantation in view of the poor long-term graft and patient outcomes. Recent literature has shown improvement/stabilization of native kidney disease following the use of bortezomib. We present 2 cases of LCDD after transplantation with graft dysfunction. They were both treated with different therapeutic agents to induce remission. Because sustained remission was not achieved they received bortezomib following which they have experienced a prolonged period of stable renal function with no clinically detectable disease. These unique cases highlight the possibility to achieve long-term stable graft function and disease remission after renal transplantation for LCDD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transplantation Proceedings - Volume 48, Issue 1, JanuaryâFebruary 2016, Pages 255-258
Journal: Transplantation Proceedings - Volume 48, Issue 1, JanuaryâFebruary 2016, Pages 255-258
نویسندگان
S. Kuppachi, D. Holanda, C.P. Thomas,