کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6247582 | 1284518 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Brain Death Is Associated With Endoplasmic Reticulum Stress and Apoptosis in Rat Liver
ترجمه فارسی عنوان
مرگ مغزی همراه با استرس رتیکولوم اندوپلاسمی و آپوپتوز در کبد موش صحرایی
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
عمل جراحی
چکیده انگلیسی
Cell death pathways initiated by stress on the endoplasmic reticulum (ER) have been implicated in a variety of common diseases, such as ischemia/reperfusion injury, diabetes, heart disease, and neurodegenerative disorders. However, the contribution of ER stress to apoptosis and liver injury after brain death is not known. In the present study, we found that brain death induces a variety of signature ER stress markers, including ER stress-specific X box-binding protein 1 and up-regulation of glucose-regulated protein 78. Furthermore, brain death causes up-regulation of C/EBP homologous protein and caspase-12. Consistent with this, terminal deoxynucleotidyl transferase-mediated 2â²-deoxyuridine 5â²-triphosphate nick-end labeling assay and transmission electron microscopy confirmed apoptosis in the liver after brain death. Taken together, the present study provides strong evidence supporting the presence and importance of ER stress and response in mediating brain death-induced apoptosis and liver injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transplantation Proceedings - Volume 46, Issue 10, December 2014, Pages 3297-3302
Journal: Transplantation Proceedings - Volume 46, Issue 10, December 2014, Pages 3297-3302
نویسندگان
S. Cao, T. Wang, B. Yan, Y. Lu, Y. Zhao, S. Zhang,