Frontiers in TransplantationIschemia-reperfusion injuryCan Ischemia-Modified Albumin Be Used as an Objective Biomarker for Renal Ischemic Damage? An Experimental Study With Wistar Albino Rats

IntroductionThis study sought to evaluate the correlation of ischemia-modified albumin (IMA) with time-dependent renal ischemic injury.MethodsWe established 5 groups of 8 Wistar albino rats as follows: sham, 10 minutes of renal ischemia, 20 minutes of renal ischemia, 30 minutes of renal ischemia, and 40 minutes of renal ischemia. Renal ischemia was established by occlusion of the right renal pedicle. Blood samples were obtained after exploration of the renal pedicle in the sham group and after thoracotomy and directly from the cardiac chambers at the end of the ischemic period in the other groups. The ischemic kidneys were removed for histopathological evaluation, and the rats were killed.ResultsThere were significant differences among the IMA levels of the 5 groups (P = .0013). Pathological examination showed that renal ischemic injury corresponded to the duration of ischemia. In the group analysis, the pathological evaluation scores were significantly different among the groups (P < .001).ConclusionsThis study shows that IMA levels can be used as a nonselective biomarker for renal ischemic injury. However, further studies are needed to support our findings.