Cardioprotection of 17,18-Epoxyeicostetraenoic Acid in Ischemia/Reperfusion Is Mediated by Cyclooxygenase-2: A Study in a Rat Model

Our data show that the cardio-depressive effects of 17,18-epoxyeicostetraenoic acid are comparable with the postischemic effluent and are mediated by cyclooxygenase-2. Our results suggest a potential cardioprotective role of the eicosanoid 17,18-epoxyeicostetraenoic acid in heart ischemia/reperfusion injury.