کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6249637 | 1284550 | 2011 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Liver transplantationExamination of Claudin-1 Expression in Patients Undergoing Liver Transplantation Owing to Hepatitis C Virus Cirrhosis Liver transplantationExamination of Claudin-1 Expression in Patients Undergoing Liver Transplantation Owing to Hepatitis C Virus Cirrhosis](/preview/png/6249637.png)
The cell adhesion molecule claudin-1 (CLDN-1) is a well known co-factor for the cell entry of hepatitis C virus (HCV). We examined 24 hepatic biopsies from liver transplant patients. Reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemistry were performed according to standard procedures. RT-PCR results were shown as relative expression (ÎCT) with beta-actin as the reference gene. Immunohistochemistry results are shown by morphometry. The CLDN-1 mRNS expression rate was significantly lower when the patient displayed favorably with an unsatisfactory to antiviral therapy 0.756 ± 0.249 versus 1.304 ± 0.28 (P = .012). There was also a strong positive correlation between CLDN-1 protein expression and liver fibrosis (Pearson correlation coefficients: r = 0.476; P = .034).
Journal: Transplantation Proceedings - Volume 43, Issue 4, May 2011, Pages 1267-1271