Clinical ScienceThe fate of unscreened women in colon cancer: impact on staging and prognosis

- We included 1,071 surgically treated colon cancer patients, including 919 patients of screening age.
- Unscreened women presented with far more advanced colon cancer.
- These unscreened women subsequently have higher mortality.
- This confirms that disparities in screening lead to disparities in outcomes.

BackgroundSeveral nationwide reports show lower female participation in colon cancer screening. We therefore assessed for outcome differences in women of screening age presenting for surgical treatment of colon cancer patients.MethodsAll patients over 50 years undergoing surgery for first-onset colon cancer at Massachusetts General Hospital (2004 to 2011) were included. Differences between (unscreened) women and the remaining population in presentation characteristics and subsequent morbidity and mortality were assessed.ResultsWe included 919 patients (49.1% female). Women were less often diagnosed through screening (26.4 vs 32.7%, P = .036). Unscreened women were at significantly higher risk (all P < .001) for having high-grade tumors (Relative risk [RR] = 1.61), lymph node metastasis (RR = 1.36), and distant metastasis (RR = 2.26) on pathology, leading to higher colon cancer-related mortality (RR = 1.72).ConclusionUnscreened women present with more advanced colon cancer and higher mortality, confirming that disparities in screening lead to ever-increasing disparities in outcomes.