کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6250853 1611955 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original researchOptimal cytoreduction, depth of myometrial invasion, and age are independent prognostic factors for survival in women with uterine papillary serous and clear cell carcinomas
ترجمه فارسی عنوان
تحقیقات علمی سیتوروداکسازی اپتیما، عمق نفوذ مایومتری و سن، عوامل پیشآگهی مستقل برای بقا در زنان با کارسینوم سلولهای سرطانی و پاپیلر رحم
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
چکیده انگلیسی


- Uterine papillary serous carcinoma (UPSC) and clear-cell carcinomas (UCCC) are associated with poor prognosis.
- Treatment options for patients with UPSC and UCCC include complete surgical staging, chemotherapy, and radiotherapy.
- Optimal cytoreduction, myometrial invasion and age are the factors affecting survival in patients with such tumors.

ObjectiveThe purpose of this study was to investigate the clinicopathological characteristics, treatment methods, and prognostic factors in women with uterine papillary serous carcinoma (UPSC) and uterine clear-cell carcinoma (UCCC).Study designAll patients who had undergone surgery for UPCS and UCCC between January 1995 and December 2012 were retrospectively reviewed. Patients with missing data, who did not undergo surgical staging and patients with mixed tumor histology were excluded. Multivariate regression models were used to identify the risk factors for overall survival (OS) and progression-free survival (PFS).ResultsA total of 49 UPSC and 22 UCCC women were included. The majority of the patients were at stage I [IA, 22 (31%) and IB, 18 (25.4%)]. Stages II, III, and IV were identified in 9 (12.7%), 13 (18.3%), and 9 (12.7%) of cases, respectively. Optimal cytoreduction was achieved in 71.8% of cases. Recurrences occurred in 16 patients (22.5%). The 5-year OS rates were 67% for UPSC; 76% for UCCC; 68% for both histology, respectively. Multivariate analysis pointed out that age > 67 years (odds ratio (OR): 3.85, p = 0.009 and OR: 3.35, p = 0.014), >50% myometrial invasion (MI) (OR: 2.87, p = 0.037 and OR: 2.46, p = 0.046) and optimal cytoreduction (OR: 3.26, p = 0.006 and OR: 2.77, p = 0.015) were the independent prognostic factors for both PFS and OS.ConclusionsOur study demonstrated that optimal cytoreduction, >50% MI, and age >67 years are the most significant factors affecting survival in women with UPSC and UCCC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Surgery - Volume 32, August 2016, Pages 71-77
نویسندگان
, , , , , , , ,