Original researchEffects of lazaroid U-74389G on intestinal ischemia and reperfusion injury in porcine experimental model

- The MDA in the groups that the lazaroid was used was decreased in comparison with the final time groups without U-74389G.
- The TNF was decreased in the two groups 60 rep + drug, 120 rep + drug compared to groups without U-74389G administration.
- In the group 120 rep + drug, where the lazaroid was administrated the histopathology score was significantly reduced.

Background: The readmission of molecular oxygen into an ischemic tissue promotes the oxidation of resuscitated tissue with certain pathophysiologic mechanisms. Materials and methods: Twenty four pigs (male or female) were randomized in this study. The animals were allocated to four groups with an equal number (n = 6) in each group: 1) control group-ischemia for 30 min and reperfusion for 60 min. 2) control group-ischemia for 30 min and reperfusion for 120 min. 3) ischemia for 30 min and immediate iv injection of lazaroid U-74389G and reperfusion for 60 min. 4) ischemia for 30 min and immediate iv injection of lazaroid U-74389G and reperfusion for 120 min. Results: We investigated further the role of an antioxidant molecule such as U-74389G and we concluded that there is statistically significant relation in MDA (malondialdeyde), TNF -α (tumor necrosis factor-α) measurement in tissue, while the histological score in the groups that the lazaroid was administered was improved. Conclusions: In many emergency clinical situations, such as reperfusion of the intestine, the role of U-74389G can be protective.