کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6251616 1611981 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original researchGentamicin-containing collagen implant reduces sternal wound complications after cardiac surgery: A retrospective analysis
ترجمه فارسی عنوان
ایمپلنت کلاژن حاوی ژنتمایسین باعث کاهش عوارض زخم ناشی از جراحی قلب می شود. یک تحلیل گذشته نگر
کلمات کلیدی
جراحی قلب، ایمپلنت کلاژن حاوی جنتامایسین، عفونت محل جراحی، عفونت زخم سینه، عفونت زخم
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
چکیده انگلیسی


- Addition of GCCI to systemic antibiotic prophylaxis reduces the risk of SWI.
- These results were obtained in high-risk patients undergoing cardiac surgery.
- GCCI should be used dry prior to insertion to optimize the prophylactic effect.
- New risk factors may help to profile patients at risk of developing SWI.

Introduction: The majority of evidence for use of gentamicin-containing collagen implants (GCCI) demonstrates a positive impact on infection prophylaxis despite the equivocal results of a recently published large-scale study. The primary aim of the study was to evaluate the impact of prophylactic use of GCCI on SWI following cardiac surgery in a routine clinical setting. A secondary aim was to identify the risk factors for SWI among the patient cohort. Methods: A consecutive series of patients who had undergone sternotomy were analysed on a retrospective basis. Patient characteristics, risk factors and procedure-related variables were analysed for Group I (superficial sternal wound infection [SSWI]) and Group II (deep sternal wound infection [DSWI]) in relation to patients with complete wound healing. Results: A total of 1118 patients met the inclusion criteria. The bivariate analysis demonstrated that the SSWI rate was significantly reduced by 43% in the GCCI group vs. standard treatment. Multivariate analysis demonstrated that addition of GCCI to standard treatment reduced the DSWI rate by 59% vs. standard treatment alone. Arterial hypertension, permanent/persistent atrial fibrillation and chest revision were identified as new risk factors for SSWI and pulmonary hypertension and chest revision were identified as new risk factors for DSWI. Discussion: This study confirms the positive results with GCCI seen in the majority of published studies in cardiac surgery. Conclusion: In routine clinical practice the addition of GCCI to standard infection prophylaxis reduces the risk of both SSWI and DSWI in high-risk patients undergoing cardiac surgery.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Surgery - Volume 13, January 2015, Pages 198-206
نویسندگان
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