کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6251717 | 1611986 | 2014 | 5 صفحه PDF | دانلود رایگان |

- Oxidized regenerated cellulose (ORC) is a standard of care hemostatic pad.
- Hemopatch is a novel protein-reactive polyethylene glycol-coated collagen pad, PCC.
- PCC provides faster hemostasis than ORC in animal models of vascular and hepatic surgery.
Purpose: Currently available hemostatic pads are effective in treating oozing bleeds, but otherwise ineffective in more severe bleeding. This study investigates the hemostatic efficacy of a new hemostatic pad with advanced sealing properties using protein-reactive polyethylene glycol-coated collagen (PCC, Hemopatch) versus an oxidized regenerated cellulose (ORC, Tabotamp/Surgicel Original) in a leporine arterial bleeding model of vascular reconstruction and a porcine hepatic model of general surgery. Methods: In both models, paired lesions were created and treated according to a randomized scheme and evaluated up to 10Â min after application (40 lesions/group/model). Arterial needle holes were created in the femoral arteries of anesthetized rabbits and hepatic lesions were created into hepatic parenchyma of anesthetized pigs. Both models were heparinized to mimic clinical comorbidity. Results: In the leporine vascular surgical model, PCC provided superior hemostatic success compared to ORC at 2Â min (Odds Ratio of Success: 85, 95% CI: 25.8-282) and similar hemostatic success at 10Â min. In the porcine hepatic model, PCC provided superior hemostatic success compared to ORC at 2 (98 vs 55%, PÂ <Â 0.001), 3 (93 vs 65%, PÂ <Â 0.001), 4 (98 vs 68%, PÂ <Â 0.001) and 5Â min (95 vs 80%, PÂ <Â 0.001), but similar hemostatic success at 8 and 10Â min. Discussion: PCC provided 75.4% greater hemostatic success at 2Â min in the arterial model and was at least 100 times more likely to be hemostat effective at 2Â min in the hepatic model than ORC. Conclusions: PCC provided faster hemostasis than ORC in a vascular and hepatic surgical model with impaired coagulation.
Journal: International Journal of Surgery - Volume 12, Issue 9, September 2014, Pages 940-944