کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6253337 1288387 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
VascularIdentification of proteins regulated by curcumin in cerebral ischemia
ترجمه فارسی عنوان
شناسایی عروق پروتئین های تنظیم شده توسط کورکومین در ایسکمی مغزی
کلمات کلیدی
کرکومین، سکته مغزی پروتئومیکس،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
چکیده انگلیسی

BackgroundCurcumin is known to have a neuroprotective effect against cerebral ischemia. The objective of this study was to identify various proteins that are differentially expressed by curcumin treatment in focal cerebral ischemia using a proteomic approach.MethodsAdult male rats were treated with vehicle or curcumin 1 h after middle cerebral artery occlusion. Brain tissues were collected 24 h after the onset of middle cerebral artery occlusion, and cerebral cortices proteins were identified by two-dimensional gel electrophoresis and mass spectrometry.ResultsWe detected several proteins with altered expression levels between vehicle- and curcumin-treated animals. Among these proteins, ubiquitin carboxy-terminal hydrolase L1, isocitrate dehydrogenase, adenosylhomocysteinase, and eukaryotic initiation factor 4A were decreased in the vehicle-treated animal, and curcumin treatment attenuated the injury-induced decreases of these proteins. Conversely, pyridoxal phosphate phosphatase was increased in the vehicle-treated animal, and curcumin treatment prevented decreases in this protein. The identified altered proteins are associated with cellular metabolism and differentiation.ConclusionsThe results of this study suggest that curcumin exerts a neuroprotective effect by regulating the expression of various proteins in focal cerebral ischemia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Surgical Research - Volume 201, Issue 1, March 2016, Pages 141-148
نویسندگان
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