کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6253667 1288401 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Shock/Sepsis/Trauma/Critical CareBetulinic acid negates oxidative lung injury in surgical sepsis model
ترجمه فارسی عنوان
شوک / سپسیس / تروما / مراقبت بحرانی بتولینیک اسید، آسیب ریه اکسیداتیو را در مدل سپسیس جراحی کاهش می دهد
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
چکیده انگلیسی

BackgroundSepsis commonly progresses to acute lung injury and is associated with high morbidity and mortality. Septic acute lung injury is characterized by severe oxidative stress response, remained refractory to present therapies, and new therapies need to be developed to improve further clinical outcomes. We determined the effect of betulinic acid (BA) on oxidative lung injury in mice using cecal ligation and puncture (CLP) model.Materials and methodsFive groups of mice (six in each group) received three pretreatments at 24-h interval before surgery. Surgery was done 1 h after last dosing. Sham and CLP control group mice received vehicle. BA was administered to other three groups of mice at 3, 10, and 30 mg/kg dose. Lung and plasma samples were collected for analysis by sacrificing the mice at 18 h of surgery.ResultsCompared with sham, CLP significantly increased total protein, nitrite, malondialdehyde, isoprostane, superoxide, protein carbonyl, oxidative stress index, inducible nitric oxide synthase protein, and histopathologic changes and reduced the superoxide dismutase, catalase activity, and total thiol levels in lungs and plasma, which were restored by BA pretreatment.ConclusionsBA pretreatment decreased the levels of oxidants, increased the levels of antioxidants in lungs and plasma thereby reducing the oxidative lung injury in CLP mice. Additionally, BA was found to scavenge the superoxide and nitric oxide radical in vitro. Thus, BA is suggested to be effective in treatment of oxidative lung injury in sepsis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Surgical Research - Volume 193, Issue 2, February 2015, Pages 856-867
نویسندگان
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