کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6256462 1612940 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The recognition of a novel-object in a novel context leads to hippocampal and parahippocampal c-Fos involvement
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
The recognition of a novel-object in a novel context leads to hippocampal and parahippocampal c-Fos involvement
چکیده انگلیسی


- Role of context change in a one-trial-novel object recognition task was studied.
- Two conditions:OR-NORMAL(sample and probe same context):OR-CONTEXT (different).
- OR-NORMAL greater exploration of objects than OR-CONTEXT.
- c-Fos involves hippocampus, entorhinal and temporal association cortices in the task.

Contextual memory implies recognition based on the association between past and present events experienced. It is important for daily functioning and dysfunctional in many neuropsychological disturbances. The network related to this memory is still open for debate, even though it has been associated with medial temporal lobe regions, including the perirhinal, entorhinal and temporal association cortices, as well as the hippocampus and prefrontal cortex. Our work tries to elucidate whether a change in the context, such as differences in the amount of stimuli presented on the walls and floor of an open field during object exploration, affects the recognition of an object that has been experienced before, and whether this context manipulation could be linked to changes in c-Fos expression. For this purpose, we used a one-trial novel-object recognition task. The animals were divided into two different experimental conditions; in the OR-NORMAL group, the sample and probe test were performed in the same context. However, in the OR-CONTEXT group, the probe test was performed in a different context. Our results showed that the OR-NORMAL group presented a greater exploration of objects than the OR-CONTEXT group. However, both groups presented significant exploration of the novel object. To label the brain regions involved in novel-object recognition under these conditions, we marked the expression of c-Fos protein. Results suggest that a neural circuit that includes the hippocampus, entorhinal and temporal association cortices is involved in the recognition of the novel-object in a novel context.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 292, 1 October 2015, Pages 44-49
نویسندگان
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