کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6257379 1612955 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewThe role of serotonin in adult hippocampal neurogenesis
ترجمه فارسی عنوان
بررسی نقش سروتونین در نوروژنز هیپوکامپ بالغ
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- Serotonin is a crucial monoamine in regulating adult hippocampal neurogenesis.
- Acute manipulation has long-term effects with distinctive actions of 5-HT receptors.
- Genetically modified animals reveal conflicting results on serotonins modulatory role.
- Serotonin mediates the pro-proliferative effect of running.
- Serotonin is pharmacologically relevant by mediating antidepressant response.

Serotonin is probably best known for its role in conveying a sense of contentedness and happiness. It is one of the most unique and pharmacologically complex monoamines in both the peripheral and central nervous system (CNS). Serotonin has become in focus of interest for the treatment of depression with multiple serotonin-mimetic and modulators of adult neurogenesis used clinically. Here we will take a broad view of serotonin from development to its physiological role as a neurotransmitter and its contribution to homeostasis of the adult rodent hippocampus. This chapter reflects the most significant findings on cellular and molecular mechanisms from neuroscientists in the field over the last two decades. We illustrate the action of serotonin by highlighting basic receptor targeting studies, and how receptors impact brain function. We give an overview of recent genetically modified mouse models that differ in serotonin availability and focus on the role of the monoamine in antidepressant response. We conclude with a synthesis of the most recent data surrounding the role of serotonin in activity and hippocampal neurogenesis. This synopsis sheds light on the mechanisms and potential therapeutic model by which serotonin plays a critical role in the maintenance of mood.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 277, 15 January 2015, Pages 49-57
نویسندگان
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