Keywords: BLA; basolateral amygdaloid nucleus, anterior part; BLP; basolateral amygdaloid nucleus, posterior part; Ce; central amygdaloid nucleus; Cg1; cingulate cortex, area 1; CRF; corticotropin-releasing factor; DR; dorsal raphe nucleus; DRC; dorsal raphe nucleu
مقالات ISI (ترجمه نشده)
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Keywords: 5-HT; serotonin (5-hydroxytryptamine); A83-01; TGF-β kinase/activin receptor-like kinase inhibitor; ACTB; actin beta/beta-actin; ASCL1; achaete-scute homolog 1 (MASH1); ASOs; anti-sense oligonucleotides; Bcl-xL; b-cell lymphoma-extra large; BDNF; brain d
Keywords: CKD; chronic kidney disease; CKD-MBD; CKD-related Mineral and Bone Disorder; 5-HT; serotonin; 5-HIAA; 5-hydroxyindoleacetic acid; TRP; tryptopha; BDS; brain-derived serotonin; Tph2; tryptophan hydroxylase-2; SNS; sympathetic nervous system; β2-adr-R; β2
Keywords: SLC6A4; serotonin transporter gene; 5-HTTLPR; serotonin transporter-linked polymorphic region; MAOA; monoamine oxidase A gene; MAOA-uVNTR; monoamine oxidase A upstream variable number of tandem repeats; TPH2; tryptophan hydroxylase-2 gene; HTR1A; serotoni
Keywords: 8-OHG; 8-hydroxyguanosine; HNE; hydroxy-2-nonenal; IF; immunofluorescence; MEFs; mouse embryonic fibroblasts; PBS; phosphate-buffered saline; TPH2; tryptophan hydroxylase-2; ZS; Zellweger syndrome; Zellweger syndrome; PEX13 deficiency; mitochondria; oxida
Keywords: Major depressive disorder; Late-onset; Cognitive function; TPH2
Keywords: Macaca mulatta; neuroethology; primate; rhesus macaque; serotonin pathway; social attention; TPH2; vigilance;
Keywords: Neuromodulator; TPH2; 5-HT receptor; Antidepressant; Neurogenic niche; BrdU;
Keywords: BH4; tetrahydrobiopterin; DSF; differential scanning fluorimetry; L-Dopa; (S)-3,4-dihydroxyphenylalanine; PAH; phenylalanine hydroxylase; PKU; phenylketonuria; TH; tyrosine hydroxylase; THD; TH deficiency; TPH2; tryptophan hydroxylase isoform 2; PD; Parki
Keywords: Huntington׳s disease,; Depression,; Tryptophan hydroxylase-2; TPH2;
Keywords: AADC; aromatic l-amino acid decarboxylase; AANAT; arylalkylamine-N-acetyltransferase; ASMT; acetylserotonin methyltransferase; DMSO; dimethyl sulfoxide; EDTA; ethylenediaminetetraacetic acid; EGTA; ethylene glycol tetraacetic acid; EPL; external plexiform
Keywords: BSTv; ventral bed nucleus of the stria terminalis; DBH; dopamine β-hydroxylase; EPM; elevated plus maze; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; TBS; Tris-buffered saline; TBS-T; Tris-buffered saline with 0.05% Tween-20; TPH2; tryptophan hydroxy
Keywords: HSR; highly stress resilient; MSR; medium stress resilient; SS; stress sensitive; TPH2; tryptophan hydroxylase 2; SERT; serotonin reuptake transporter; 5HT1A; serotonin 1A receptor; ISH; in situ hybridization; IHC; immunohistochemistry; ANOVA; analysis of
Dorsal raphé nucleus glucocorticoid receptors inhibit tph2 gene expression in male C57BL/6J mice
Keywords: AAV2/9-Cre, AAV2/9-GFP; pseudotyped adeno-associated virus 2/9 transducing either Cre recombinase or green fluorescent protein; DRN; dorsal raphé nucleus; DRD, DRC, DRI; dorsal, caudal and interfascicular parts of the dorsal raphé nucleus; GR; glucocort
Transcriptome of the Wistar audiogenic rat (WAR) strain following audiogenic seizures
Keywords: 5-HT; Serotonin; Acsm3; Acyl-CoA synthetase medium-chain family member 3; Acsm5; Acyl-CoA synthetase medium-chain family member 5; aGPCR; G protein-coupled adhesion receptors; ANOVA; analysis of variance; AS; audiogenic seizure; BH4; tetrahidropteridina;
TGF-β Signaling Regulates Development of Midbrain Dopaminergic and Hindbrain Serotonergic Neuron Subgroups
Keywords: 5-HT; 5-hydroxytryptamine; Aldh1a1; aldehyde dehydrogenase 1 family member A1; Cck; cholecystokinin; cKO; conditional knockout; DIV; day in vitro; DR; dorsal raphe; MR; median raphe; PMR; paramedian raphe; RM; raphe magnus; En1; engrailed 1; ES; embryonic
TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis
Keywords: TPH2; Candidate gene; Depression; Major depressive disorder; Mood disorders; Suicide; Serotonin; Single nucleotide polymorphism; SNP; Schizophrenia; Bipolar disorder; Association study; Tic disorder; Autism; ADHD; Anxiety disorders;
Exposure to Acute and Chronic Fluoxetine has Differential Effects on Sociability and Activity of Serotonergic Neurons in the Dorsal Raphe Nucleus of Juvenile Male BALB/c Mice
Keywords: 5-HT; 5-hydroxytryptamine, serotonin; 5-HTP; 5-hydroxytryptophan; AADC; aromatic amino acid decarboxylase; ASD; autism spectrum disorder; DR; dorsal raphe nucleus; DRC; dorsal raphe nucleus, caudal part; DRD; dorsal raphe nucleus, dorsal part; HPLC; high
Optogenetic activation of 5-HT neurons in the dorsal raphe suppresses seizure-induced respiratory arrest and produces anticonvulsant effect in the DBA/1 mouse SUDEP model
Keywords: AGSz; audiogenic seizures; ChR2; Channelrhodopsin-2; DBS; deep brain stimulation; DR; dorsal raphe; 5-HT; serotonin; 5-HTP; 5-hydroxytryptophan; OND; ondansetron; PTZ; pentylenetetrazole; S-IRA; seizure-induced respiratory arrest; SSRI(s); selective serot
Impairment of learning and memory performances induced by BPA: Evidences from the literature of a MoA mediated through an ED
Keywords: Bisphenol A; Endocrine disruption; Learning and memory; Nervous system; 5α-R; 5 α-reductase; AChE; acetylcholinesterase; Akt; protein kinase B; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ANSES; Agence Nationale de Sécurité Sanitaire
Association of regulatory TPH2 polymorphisms with higher reduction in depressive symptoms in children and adolescents treated with fluoxetine
Keywords: Fluoxetine; Pharmacogenetics; Children; TPH2; Polymorphism; rs34517220;
Preimmunization with a heat-killed preparation of Mycobacterium vaccae enhances fear extinction in the fear-potentiated startle paradigm
Keywords: Actinobacteria; Acoustic startle; Fear-potentiated startle; htr1a; Mycobacteria; Mycobacterium vaccae; Organic cation transporter 3; slc22a3; slc6a4; tph2;
Xiaochaihutang attenuates depressive/anxiety-like behaviors of social isolation-reared mice by regulating monoaminergic system, neurogenesis and BDNF expression
Keywords: XCHT; Xiaochaihutang; SI; social isolation; TST; tail suspension test; FST; forced swimming test; OFT; open field test; EPM; elevated-plus maze; AT; intruder-induced aggression test; GLU; glutamic acid; GABA; γ-aminobutyric acid; 5-HT; 5-hydroxyptramine;
A comparison of biomarker responses in juvenile diploid and triploid African catfish, Clarias gariepinus, exposed to the pesticide butachlor
Keywords: BUC; Butachlor; VSI; visceral-somatic index; HSI; Hepatosomatic index; CF; Condition factor; GnRH; Gonadotropin-releasing hormone; tph2; Tryptophan hydroxylase2; cyp191b; Brain aromatase; foxl2; Forkhead box L2; ftz-f1; Fushi tarazu-factor 1; 11β-hsd2; 1
Diploid and triploid African catfish (Clarias gariepinus) differ in biomarker responses to the pesticide chlorpyrifos
Keywords: CPF; chlorpyrifos; VSI; visceral-somatic index; HSI; hepatosomatic index; CF; condition factor; TLC; total length change; TWC; total weight change; GnRH; gonadotropin-releasing hormone; tph2; tryptophan hydroxylase2; cyp19a2; brain aromatase; foxl2; forkh
Effect of family structure and TPH2 G-703T on the stability of dysregulation profile throughout adolescence
Keywords: TPH2; 5-HTTLPR; Emotional dysregulation; Adolescence; Family structure; Dysregulation profile;
Acute phenanthrene toxicity to juvenile diploid and triploid African catfish (Clarias gariepinus): Molecular, biochemical, and histopathological alterations
Keywords: Polyploidy; Fish; Biomarkers; Biochemical; Gene expressions; Histopathology; Phe; phenanthrene; TP; total protein; AST; aspartate aminotransferase; ALT; alanine aminotransferase; LDH; lactate dehydrogenase; ALP; alkaline phosphatase; γGT; gamma-glutamyl
Virgin microplastics cause toxicity and modulate the impacts of phenanthrene on biomarker responses in African catfish (Clarias gariepinus)
Keywords: MPs; Microplastics; PE; Polyethylene; LDPE; Low-density polyethylene; Phe; Phenanthrene; GnRH; Gonadotropin-releasing hormone; tph2; Tryptophan hydroxylase2; cyp19a2; Brain aromatase; foxl2; Forkhead box L2; ftz-f1; Fushi tarazu-factor 1; 11β-hsd2; 11 β
Olanzapine augments the effect of selective serotonin reuptake inhibitors by suppressing GABAergic inhibition via antagonism of 5-HT6 receptors in the dorsal raphe nucleus
Keywords: Olanzapine; Selective serotonin reuptake inhibitor; Serotonergic neurons; 5-HT6 receptor; GABAergic neurons; Depression; ANOVA; analysis of variance; GABA; γ-aminobutyric acid; GAD; glutamate decarboxylase; DMSO; dimethyl sulfoxide; DRN; dorsal raphe nuc
Tryptophan hydroxylase 2 (TPH2) gene polymorphisms and psychiatric comorbidities in temporal lobe epilepsy
Keywords: Epilepsy; Alcohol abuse; Serotonergic system; 5-HTT; TPH2
Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity
Keywords: Serotonin; TPH2; Gene polymorphism; Anxiety; Depression-like behavior; 5-HT1A receptor;
Convergent effects of mouse Pet-1 deletion and human PET-1 variation on amygdala fear and threat processing
Keywords: BLA; basolateral amygdala; EtOH; ethanol; Pet-1, FEV; Pheochromocytoma 12 ets; KO; knockout; PTSD; posttraumatic stress disorder; PL; prelimbic cortex; 5-HTT; the serotonin transporter; Tph2; tryptophan hydroxylase-2; vmPFC; ventromedial prefrontal cortex
Opiate exposure and withdrawal dynamically regulate mRNA expression in the serotonergic dorsal raphe nucleus
Keywords: 5-HT; serotonin; BDNF; brain-derived neurotrophic factor; CPP; conditioned place-preference; CRF; corticotrophin-releasing factor; DRN; dorsal raphe nucleus; FS; forced swim; GABAA-α1; alpha 1 subunit of the GABAA receptor; MOR; μ-opioid receptor; PCR;
Genetic association and gene-gene interaction analyses suggest likely involvement of ITGB3 and TPH2 with autism spectrum disorder (ASD) in the Indian population
Keywords: TPH2; tryptophan hydroxylase 2; ITGB3; integrin beta chain 3; LD; linkage disequilibrium; ASD; autism spectrum disorder; TDT; transmission disequilibrium test; MDR; multifactor dimensionality reduction; FASTSNP; function analysis and selection tool for si
Monoamine neurocircuitry in depression and strategies for new treatments
Keywords: 5-HT; 5-hydroxytryptamine, serotonin; BDNF; brain derived neurotrophic factor; CA; catecholamines; Cg25; subgenual cingulate (Brodmann area 25); CNS; central nervous system; CO-MED; Combining Medications to Enhance Depression Outcomes; CRH; corticotropin-
Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients
Keywords: Multiple sclerosis; Melatonin pathway genes; Single nucleotide polymorphisms (SNPs); TPH2; MTNR1B; Expanded Disability Status Scale (EDSS);
Caffeine interferes embryonic development through over-stimulating serotonergic system in chicken embryo
Keywords: DA; dopamine hydrochloride; DOPAC; 3,4-dihydroxyphen-ylanetic acid; HVA; homovanillic acid; TPH2; tryptophan hydroxylase 2; 5-HT; 5-hydroxytryptamine; 5-HIAA; 5-hydroxyindoleac-etic acid; Caffeine; Brain; Monoamine neurotransmitter; 5-HT; Neural tube; Chi
Stress-induced activation of the brainstem Bcl-xL gene expression in rats treated with fluoxetine: Correlations with serotonin metabolism and depressive-like behavior
Keywords: 5-HT1A receptor; 5-HT turnover; Bcl-xL; Fluoxetine; Stress; TPH2;
Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics
Keywords: TPH2; Schizophrenia; Association study; Response antipsychotics; Cognition; PPI
TPH2 polymorphisms and alcohol-related suicide
Keywords: TPH2; Polymorphism; Slavic/Slovenian population; Suicide; Alcoholism; Impulsivity
Development by environment interactions controlling tryptophan hydroxylase expression
Keywords: Tryptophan hydroxylase; Tph1; Tph2; Serotonin; Dorsal raphe nucleus
Multi-scale correlation structure of gene expression in the brain
Keywords: Neuroinformatics; Molecular neuroanatomy; Correlation search; Gene expression; Tph2
High novelty-seeking predicts aggression and gene expression differences within defined serotonergic cell groups
Keywords: Emotionality; Brainstem; TPH2; SERT; C-fos; Resident–intruder test
Tryptophan hydroxylase-2 (TPH2) in disorders of cognitive control and emotion regulation: A perspective
Keywords: Serotonin; Tryptophan hydroxylase; TPH1; TPH2; Knockout; Development; Anxiety aggression; Depression; Suicide; OCD; ADHD
Neurodegeneration, Neuroprotection, and Disease-Oriented NeuroscienceResearch PaperLong-term ovariectomy decreases serotonin neuron number and gene expression in free ranging macaques
Keywords: Fev; TPH2; serotonin reuptake transporter; 5HT1A autoreceptor; estrogen; progesterone; fenfluramine; E; estradiol; ISH; in situ hybridization; ONPRC; Oregon National Primate Research Center; Ovx; ovariectomized; P; progesterone; SERT; serotonin reuptake t
Effects of citalopram on serotonin and CRF systems in the midbrain of primates with differences in stress sensitivity
Keywords: Corticotropin releasing factor; Urocortin; Fev; TPH2; SLC6A4; 5HT1A; CRF-R2; Macaques
Tryptophan-hydroxylase 2 haplotype association with borderline personality disorder and aggression in a sample of patients with personality disorders and healthy controls
Keywords: Borderline personality disorder; TPH2; Suicidal behavior; Affective instability; Impulsive aggression;
Influence of functional tryptophan hydroxylase 2 gene variation and sex on the startle response in children, young adults, and older adults
Keywords: Acoustic startle response; TPH2; Functional gene variation; Sex; Age; Fear;
Estrogen receptor (ER) subtype agonists alter monoamine levels in the female rat brain
Keywords: ovx; ovariectomized; ER; estrogen receptor; E; 17β-estradiol; C19; 4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one; PPT; 4,4â²,4â³-(4-propyl-{1H}-pyrazole-1,3,5-triyl)trisphenol; DPN; diarylpropionitrile; HPLC; high performance liquid c
Monoamine deficits in the brain of methyl-CpG binding protein 2 null mice suggest the involvement of the cerebral cortex in early stages of Rett syndrome
Keywords: RTT; neurodevelopment; autism; mental retardation; norepinephrine; serotonin; Adrα2a; adrenergic receptor α2a; Adrβ2; adrenergic receptor β2; ANOVA; analysis of variance; BSA; bovine serum albumin; CSF; cerebrospinal fluid; DA; dopamine; DAB; diaminob