کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6017944 | 1580182 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Convergent effects of mouse Pet-1 deletion and human PET-1 variation on amygdala fear and threat processing
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کلمات کلیدی
EtOHBLAvmPFCtph25-HTTbasolateral amygdala - amygdala basolateralEthanol - اتانولPosttraumatic stress disorder - اختلال استرس پس از سانحهPTSD - اختلال استرسی پس از ضایعه روانیtryptophan hydroxylase-2 - تریپتوفان هیدروکسیلاز 2Fear conditioning - تهدید ترسSerotonin - سروتونینFev - فوmedial prefrontal cortex - قشر غده پروسترولprelimbic cortex - قشر پیش از قاعدگیknockout - ناکاوتventromedial prefrontal cortex - کورتکس prefrontal ventromedial
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Serotonin is critical for shaping the development of neural circuits regulating emotion. Pet-1 (FEV-1) is an ETS-domain transcription factor essential for differentiation and forebrain targeting of serotonin neurons. Constitutive Pet-1 knockout (KO) causes major loss of serotonin neurons and forebrain serotonin availability, and behavioral abnormalities. We phenotyped Pet-1 KO mice for fear conditioning and extinction, and on a battery of assays for anxiety- and depression-related behaviors. Morphology of Golgi-stained neurons in basolateral amygdala (BLA) and prelimbic cortex was examined. Using human imaging genetics, a common variant (rs860573) in the PET-1 (FEV) gene was tested for effects on threat-related amygdala reactivity and psychopathology in 88 Asian-ancestry subjects. Pet-1 KO mice exhibited increased acquisition and expression of fear, and elevated fear recovery following extinction, relative to wild-type (WT). BLA dendrites of Pet-1 KO mice were significantly longer than in WT. Human PET-1 variation associated with differences in amygdala threat processing and psychopathology. This novel evidence for the role of Pet-1 in fear processing and dendritic organization of amygdala neurons and in human amygdala threat processing extends a growing literature demonstrating the influence of genetic variation in the serotonin system on emotional regulation via effects on structure and function of underlying corticolimbic circuitry.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 250, December 2013, Pages 260-269
Journal: Experimental Neurology - Volume 250, December 2013, Pages 260-269
نویسندگان
Cara L. Wellman, Marguerite Camp, V. Morgan Jones, Kathryn P. MacPherson, Jessica Ihne, Paul Fitzgerald, Mouna Maroun, Emily Drabant, Ryan Bogdan, Ahmad R. Hariri, Andrew Holmes,