کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6258137 | 1612969 | 2014 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hippocampal biomarkers of fear memory in an animal model of generalized anxiety disorder
ترجمه فارسی عنوان
بیومارکرهای هیپوکامپ از حافظه ترس در یک مدل حیوانی اختلال اضطراب عمومی
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Fear memory was higher among CHF rats whilst spatial learning was preserved. Serum corticosterone levels were increased, with decreased GR expression. No differences were observed in hippocampal cell proliferation/survival, but the number of newborn neurons was decreased, along with their number and length of tertiary dendrites. Increased expression of proBDNF and dendritic spines was observed; lower ratio of GABA release in the hippocampus was also verified. These findings suggest that generalized anxiety/fear could be associated with different hippocampal biomarkers, such as increased spine density, possibly as a compensatory mechanism for the decreased hippocampal number of neuroblasts and dendritic arborization triggered by high corticosterone. Disruption of GABAergic signaling and BDNF impairment are also proposed as part of the hippocampal mechanisms possibly underlying the anxious phenotype of this model.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 263, 15 April 2014, Pages 34-45
Journal: Behavioural Brain Research - Volume 263, 15 April 2014, Pages 34-45
نویسندگان
Gisele Pereira Dias, Mário Cesar do Nascimento Bevilaqua, Anna Claudia Domingos Silveira da Luz, Renata Lopes Fleming, LÃtia Alves de Carvalho, Graham Cocks, Danielle Beckman, Lucas Costa Hosken, William de Sant'Anna Machado,