کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6259228 1612991 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Short communicationStress and estrous cycle affect strategy but not performance of female C57BL/6J mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Short communicationStress and estrous cycle affect strategy but not performance of female C57BL/6J mice
چکیده انگلیسی

Stress induces a switch in learning strategies of male C57BL/6J mice from predominantly spatial to more stimulus-response learning. To study generalization of these findings over sex, we investigated female C57BL/6J mice at three phases of the estrous cycle under non stress and acute (10 min) restraint stress conditions. On a circular hole board (CHB) task, about half of the naive female mice used spatial and stimulus-response strategies to solve the task. Under stress, female mice favored spatial over stimulus-response strategies, with 100% of female mice in the estrus phase. Performance expressed as latency to solve the task is only improved in stressed female mice in the estrus phase. We conclude that the use of learning strategies is influenced by sex and this difference between sexes is aggravated by acute stress.

► There is a sex difference in the use of learning strategies. ► Stress induces a switch from stimulus-response toward spatial strategy in female mice. ► Stressed estrus females rescue their performance by switching to a spatial learning strategy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 241, 15 March 2013, Pages 92-95
نویسندگان
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