کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6259618 | 1289990 | 2012 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Research reportAuditory discrimination training rescues developmentally degraded directional selectivity and restores mature expression of GABAA and AMPA receptor subunits in rat auditory cortex Research reportAuditory discrimination training rescues developmentally degraded directional selectivity and restores mature expression of GABAA and AMPA receptor subunits in rat auditory cortex](/preview/png/6259618.png)
Auditory frequency discrimination training can remediate deteriorated frequency representations and temporal information processing in the adult primary auditory cortex induced by early post-natal pulsed noise exposure. In this study, we investigated the neural mechanisms underlying the restoration of directional selectivity by auditory spatial discrimination training. Rats exposed to pulsed noise during a post-natal critical period demonstrated reduced auditory directional selectivity but could be successfully trained to identify a target sound stimulus at a specific azimuth angle using a reward-contingent auditory discrimination task (EXP rats). In contrast, rats passively exposed to the training procedure but no reward for correct identification of the azimuth angle (PNR rats) showed no improvement and behavioral performance remained significantly below EXP rats and control (CON) rats reared under a normal sonic environment. The expression levels of GABAA receptor subunits α1, α3, β2, and β3, and the AMPA GluR2 subunit were significantly altered in the auditory cortex of untrained noise-raised (NR and PNR) rats compared to age-matched CON rats, while trained noise-raised (EXP) rats exhibited levels of expression not significantly different from CON rats. Thus, reward-contingent sound-azimuth discrimination training may remediate directional selectivity by restoring the proper expression profile of neurotransmitter receptor subunits in the auditory cortex, allowing for normal spatial selectivity by cortical neurons. The development of auditory directional selectivity depends on the regulated expression of these excitatory and inhibitory neurotransmitter receptor subunits; early pulsed noise may disrupt the normal development of directional selectivity by interfering with receptor expression.
⺠Auditory training restores mature expression of GABAA and GluR2 receptors in adult auditory cortex. ⺠Normalization of GABAA and GluR2 receptor expression contributes to recovery of dysfunctional directional sensitivity in adult. ⺠Disrupted GABAA and GluR2 receptor expression can be reversed by auditory training in adult auditory cortex.
Journal: Behavioural Brain Research - Volume 229, Issue 2, 15 April 2012, Pages 301-307