کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6259805 | 1290005 | 2011 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Research reportTiming behavior in streptozotocin-induced diabetic rats Research reportTiming behavior in streptozotocin-induced diabetic rats](/preview/png/6259805.png)
There is evidence of deterioration of spatial cognition in streptozotocin (STZ)-induced diabetic rats. Here, we evaluate a possible dissociation in the cognitive deficits due to diabetes by examining another crucial aspect of animal cognition: temporal perception. Timing behavior and temporal memory were evaluated in STZ-induced diabetic rats employing two timing tasks: the peak-interval procedure, with its Gap variant, and the interval bisection task. A spatial memory task, rewarded alternation in the T-maze, was also evaluated to explore spatial cognition. The two timing tasks employed coincide in the finding of a normal timing performance in STZ-induced diabetic rats. The peak-interval procedure provided results that suggest that the timing behavior is equally accurate and precise than in control subjects; in the Gap procedure, an equal change in peak time in both groups indicates that temporal working memory is also intact. In the interval bisection task, we analyzed the acquisition of a temporal discrimination and the sensitivity to changes in the duration of the stimulus; no differences were found in either the acquisition process or the sensitivity index. In contrast, in the rewarded alternation task, STZ-induced diabetic rats exhibited a significant deficit in spatial cognition. The cognitive processes involved in timing behavior and temporal memory are not deteriorated as a consequence of diabetes; the cognitive deficits associated to diabetes thus seem to be restricted to the spatial domain.
⺠We explored the impact of diabetes on timing behavior and spatial cognition. ⺠A normal timing process was found in diabetic rats in the two timing tasks employed. ⺠In contrast, a deficit in spatial cognition was found in diabetic rats. ⺠Temporal and spatial cognition were differentially affected by diabetes.
Journal: Behavioural Brain Research - Volume 224, Issue 1, 10 October 2011, Pages 189-194