کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6259978 1290015 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research reportRecovery from sexual exhaustion-induced copulatory inhibition and drug hypersensitivity follow a same time course: Two expressions of a same process?
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Research reportRecovery from sexual exhaustion-induced copulatory inhibition and drug hypersensitivity follow a same time course: Two expressions of a same process?
چکیده انگلیسی

Male rats allowed copulating without restriction with a single oestrous female ejaculate repeatedly until reaching sexual exhaustion. Twenty-four hours after this process, sexually exhausted males exhibit a series of physiological alterations when compared to non-exhausted males. Among them, the most conspicuous are a long-lasting sexual behaviour inhibition and a generalised hypersensitivity to drug actions. The objective of the present work was to establish if there was a correlation between these two features of sexual satiation in relation to the duration of its expression. To that aim, we characterised the spontaneous sexual behaviour recovery process from sexual satiation, as well as the duration of the drug hypersensitivity phenomenon. The latter was assessed through the appearance of a sign of the serotonergic syndrome: the flat body posture. Results showed that the drug hypersensitivity phenomenon and the sexual inhibition that results from copulation to satiation follow a similar time course of recovery, with a drastic decrease in their expression 96 h after the sexual satiation process. This finding indicates that these phenomena might represent two expressions of a same brain plasticity process, as suggested by the long lasting character of both events, which interestingly appears to be reversible.

Research highlights▶ Copulation to satiation induces drug hypersensitivity and sexual inhibition. ▶ Both phenomena are reversible and show the same time course of recovery. ▶ A shared brain plasticity process might underlie these changes. ▶ Both phenomena could occur at the mesolimbic circuit.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 217, Issue 2, 1 March 2011, Pages 253-260
نویسندگان
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