کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6261717 1613246 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewElectrical stimulation of hippocampus for the treatment of refractory temporal lobe epilepsy
ترجمه فارسی عنوان
تحریک الکتریکی هیپوکامپ برای درمان صرع لوب مقاوم در برابر نور
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی


- The anatomical basis of hippocampus stimulation (HS) was discussed.
- The animal and clinical researches of HS were reviewed.
- The stimulation paradigm and mechanism were summarized.
- The responsive electrical stimulation clinical trials were discussed.

Temporal lobe epilepsy (TLE) is the most common epilepsy syndrome and is often associated with pharmacoresistance. Patients with pharmacoresistant TLE may be candidates for epilepsy surgery, and anterior temporal lobectomy if indicated is the most effective known treatment and has the best chance of a seizure-free outcome. For many patients with TLE, epilepsy surgery is not an option, for example when the seizure onset zone co-localizes with eloquent brain function and cannot be resected, or the seizure onset zone is not well localized, or when seizures independently originate from both temporal lobes. For many of these patients, electrical stimulation is a viable treatment option, such as electrical stimulation of the hippocampus, or temporal neocortex, or thalamus. Animal and clinical studies in humans have demonstrated electrical stimulation is an effective and safe treatment. Moreover, successful application of responsive neurostimulation system in the treatment of temporal lobe epilepsy has been reported recently. This review is intended to provide a comprehensive review of the modern history of electrical stimulation of the hippocampus for the treatment of refractory medial temporal lobe epilepsy and discuss the anatomical basis, validity, side effects, stimulation paradigm and mechanism of hippocampus stimulation and the responsive electrical stimulation trials.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 109, October 2014, Pages 13-21
نویسندگان
, , , , , , ,