|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|6261816||1613263||2013||4 صفحه PDF||سفارش دهید||دانلود رایگان|
Streptococcus agalactiae (GBS) is a major cause of severe morbidity and mortality in neonates and young infants, causing sepsis, pneumonia and meningitis. The survivors from this meningitis can suffer serious long-term neurological consequences, such as, seizures, hearing loss, learning and memory impairments. Neurotrophins, such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) control the neuronal cell death during the brain development and play an important role in neuronal differentiation, survival and growth of neurons. Neonate Wistar rats, received either 10Â Î¼L of sterile saline as a placebo or an equivalent volume of GBS suspension at a concentration of 1Â ÃÂ 106Â cfu/mL. Sixty days after induction of meningitis, the animals underwent behavioral tests, after were killed and the hippocampus and cortex were retired for analyze of the BDNF and NGF levels. In the open-field demonstrated no difference in motor, exploratory activity and habituation memory between the groups. The step-down inhibitory avoidance, when we evaluated the long-term memory at 24Â h after training session, we found that the meningitis group had a decrease in aversive memory when compared with the long-term memory test of the sham group. BDNF levels decreased in hippocampus and cortex; however the NGF levels decreased only in hippocampus. These findings suggest that the meningitis model could be a good research tool for the study of the biological mechanisms involved in the behavioral alterations secondary to GBS meningitis.
âº We evaluated the memory in adult Wistar rats submitted to meningitis in neonatal period. âº In meningitis group there was the long-term memory decrease in aversive memory task. âº The BDNF levels decreased in hippocampus and cortex when compared to the sham group. âº The NGF levels decreased only in hippocampus when compared with the sham group.
Journal: Brain Research Bulletin - Volume 92, March 2013, Pages 56-59