کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6261895 1613260 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research reportMaternal separation induces alterations of serotonergic system in different aged rats
ترجمه فارسی عنوان
گزارش تحقیقاتی جداسازی مادری باعث تغییرات سیستم سروتونرژیک در موش های صحرایی مختلف می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی


- Maternal separation (MS) increases 5-HT level in the PFC of infant rats.
- MS increases 5-HT and 5-HIAA levels in the NAc of adolescent rats.
- MS increases levels of 5-HT in PFC as well as 5-HT and 5-HIAA in NAc of adult rats.
- There is U-shaped pattern for serotonergic synthesis from younger rats to adults.
- There is inverted U-shaped pattern for serotonergic activity during three aged rats.

Maternal separation (MS) induces profound behavioral and neurochemical dysregulations in adult rodents. In the present longitudinal study, we investigated the effects of repeated (4 h/day) maternal separation during postnatal days 1-21 on serotonergic synthesis and activity in the prefrontal cortex (PFC), nucleus accumbens (NAc) and hippocampus of juvenile (post-natal day 21, PND 21), adolescent (PND 35) and early adult (PND 56) male Wistar rats. We found that MS increased 5-HT levels in the PFC of juvenile rats, and although MS increased 5-HT and 5-HIAA levels in the NAc of adolescent rats, the ratio between 5-HIAA and 5-HT decreased in the PFC. In addition, MS-treated adult rats showed increased levels of 5-HT in the PFC as well as 5-HT and 5-HIAA in the NAc. These data provided evidence that MS leads to profound and age-specific changes in serotonergic synthesis and activity in rodents. Our study also found that there are U-shaped and inverted U-shaped patterns for serotonergic synthesis and serotonergic activity from younger rats to adults, respectively. Together, our findings support the use of maternal separation as an animal model for studying the neurobiological pathogenesis of neurodevelopmental diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 95, June 2013, Pages 15-20
نویسندگان
, , , , ,